Présentation
Ressources & publications
-
2019Journal (source)IUBMB LifeGATA factor transcriptional activity: Insights from genome-wide binding profi...
-
2019Journal (source)Blood
Lentiviral and genome-editing strategies for the treatment of β-hemoglobinopa...
-
2019Journal (source)Nat Rev Drug Discov
Gene therapy targeting haematopoietic stem cells for inherited diseases: prog...
-
2019Journal (source)Mol. Ther.
Optimization of CRISPR/Cas9 Delivery to Human Hematopoietic Stem and Progenit...
-
Journal (source)Mol Ther Methods Clin Dev
An Optimized Lentiviral Vector Efficiently Corrects the Human Sickle Cell Dis...
-
2019Journal (source)Blood
Induction of fetal hemoglobin synthesis by CRISPR/Cas9-mediated editing of th...
-
2019Journal (source)Stem Cells Transl Med
Concise Review: Epigenetic Regulation of Hematopoiesis: Biological Insights a...
-
2017Journal (source)Sci Rep
Transcriptional, epigenetic and retroviral signatures identify regulatory reg...
-
2017Journal (source)Stem Cell Reports
Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratino...
-
2016Journal (source)PLoS ONE
Genome-Wide Definition of Promoter and Enhancer Usage during Neural Induction...
-
2013Journal (source)Virology
Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV...
-
2013Journal (source)PLoS ONE
Deletion of the LTR enhancer/promoter has no impact on the integration profil...
-
2012Journal (source)J. Clin. Invest.
Lentiviral vector integration in the human genome induces alternative splicin...
-
2012Journal (source)PLoS ONE
The GATA1-HS2 enhancer allows persistent and position-independent expression ...
-
2010Journal (source)Mol. Cell. Biol.
Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like gl...
-
2010Journal (source)Blood
FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity wit...
-
2010Journal (source)EMBO J.
NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during ...
-
2009Journal (source)PLoS ONE
Transcription factor binding sites are genetic determinants of retroviral int...
-
Journal (source)Proc. Natl. Acad. Sci. U.S.A.
In vivo selection of genetically modified erythroblastic progenitors leads to...
-
2008Journal (source)Dev. Biol.
The homeodomain transcription factor Prep1 (pKnox1) is required for hematopoi...
-
2007Journal (source)Blood
Hot spots of retroviral integration in human CD34+ hematopoietic cells.
-
2006Journal (source)Mol. Cell. Biol.
Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction...
-
2006Journal (source)J. Neurosci.
Phosphorylation of synapsin I by cAMP-dependent protein kinase controls synap...
-
2019Journal (source)Haematologica
Plerixafor enables safe, rapid, efficient mobilization of hematopoietic stem ...
-
2020Journal (source)Sci Adv
Editing a γ-globin repressor binding site restores fetal hemoglobin synthesis...
-
2020Journal (source)iScience
GATA Factor-Mediated Gene Regulation in Human Erythropoiesis.
-
2022Journal (source)Mol Ther
Novel genome-editing-based approaches to treat motor neuron diseases: Promise...
-
Journal (source)Prog Mol Biol Transl Sci
Genome editing approaches to β-hemoglobinopathies.
-
2022Journal (source)Nat Med
Long-term outcomes of lentiviral gene therapy for the β-hemoglobinopathies: t...
-
2022Journal (source)Nat Commun
Base-editing-mediated dissection of a γ-globin cis-regulatory element for the...
-
2023Journal (source)Mol Ther Nucleic Acids
Novel lentiviral vectors for gene therapy of sickle cell disease combining ge...
-
2024Journal (source)Blood Rev
Revolutionising healing: Gene Editing's breakthrough against sickle cell dise...
-
2023Journal (source)Mol Ther Nucleic Acids
Progress and harmonization of gene editing to treat human diseases: Proceedin...
-
Journal (source)Annu Rev Genomics Hum Genet
Sickle Cell Disease: From Genetics to Curative Approaches.
-
2023Journal (source)Blood
Adenine base editor-mediated correction of the common and severe IVS1-110 (G>...
-
2023Journal (source)Genes (Basel)
Epigenetic Regulation of β-Globin Genes and the Potential to Treat Hemoglobin...
-
2022Journal (source)Stem Cells Transl Med
CRISPRthripsis: The Risk of CRISPR/Cas9-induced Chromothripsis in Gene Therapy.
-
2022Journal (source)Mol Ther
Combination of lentiviral and genome editing technologies for the treatment o...
-
2021Journal (source)Haematologica
Fetal hemoglobin rescues ineffective erythropoiesis in sickle cell disease.
-
2021Journal (source)Blood Adv
Correction of β-thalassemia by CRISPR/Cas9 editing of the α-globin locus in h...
-
2021Journal (source)Front Genome Ed
Base and Prime Editing Technologies for Blood Disorders.
-
2021Journal (source)J Clin Med
Genome Editing for β-Hemoglobinopathies: Advances and Challenges.
-
2021Journal (source)Methods Mol Biol
A Genome Editing System for Therapeutical Targeting of Stem Cells.